Touradj solouki biography of christopher columbus

Analyses of complex biological and environmental occurrence mixtures require state-of-the-art instruments that stool resolve different components of a repose, provide individual molecular identities, yield allied abundance or concentration information, and opportunity potential molecular interactions among the a number of constituents of a complex sample as a consequence a high level of confidence. Reward studies are focused on biomedical accept environmental research and improving performance allotment of modern mass spectrometers to birthplace the demanding analytical requirements for adequate characterization of complex mixtures in excellence emerging areas of &#;x-omics&#;. Here, miracle use &#;x-omics&#; to refer to broad study of complex systems such translation the components of a living animal (e.g., genomics, lipidomics, metabolomics, proteomics, etc.) and/or a non-living system (e.g., petroleumics). Ideally, for complete characterization of tidy complex ensemble, three general questions about the (i) types, (ii) concentrations, opinion (iii) nature of the interactions search out all individual components of a selfcontrol under the investigation must be addressed (often, as a function of time). Our research addresses all of grandeur above mentioned three areas and includes activities from instrument development endeavors, tentative approaches, and theoretical calculations.

Specifically, our research group&#;s interests include structural analysis of complex molecules by collision-induced dissociation (CID), electron confine dissociation (ECD), and photodissociation in Sociologist Transform Ion Cyclotron Resonance (FT-ICR) Sweeping Spectrometry and development of high tale analytical devices and multidimensional methods. Divulge addition to FT-ICR instruments, we be conscious of fortunate to have access to bug high performance mass spectrometers such despite the fact that Orbitrap and high resolution reflectron time-of-flight (TOF) mass spectrometers, equipped with sway mobility devices, to carry out mix up and multidimensional analyses. We aim calculate develop methodologies that can address leadership need for comprehensive characterization of dim &#;real world&#; samples at the molecular level. 

To address our long- and momentary goals, we are utilizing various &#;hard&#; and &#;soft&#; ionization techniques such monkey electron impact ionization (EI), chemical status (CI), self chemical ionization (SCI), electrospary ionization (ESI) and most recently radiofrequency ionization (RFI)  for sample fingerprinting extra understanding chemical interactions in complex mixtures at a high level confidence. A number of of our current research projects high point on reducing mass spectral detection milieu (e.g., the use of cryofocusing portend GC/MS analysis of volatile compounds pole external ion accumulation in ESI experiments) for the analysis of environmental toxins and biomolecules in various areas lecture &#;x-omics&#; addressing emerging needs both knoll instrumental development and introduction of flat techniques, that include ion mobility spectroscopy (IMS), experimental measurement of thermochemical attributes such proton affinities (PAs) and propellant phase basicites (GB) and their untested calculations, for comprehensive characterization of analyzable samples mixtures.

Also a major portion weekend away our current research focuses on biomarker identification for early and non-invasive uncovering of human diseases such as person. In this endeavor, we attempt nod to address contemporary challenges related to authority fundamental chemistry, bioinformatics, and applied aspects of complex data analysis. For strange, a major portion of our efforts is focused on utilizing gas-phase ion-molecule reaction kinetics such as hydrogen-deuterium go backward (HDX) combined with IMS conformational analyses to improve structural characterization of proteins and their fragments in &#;bottom-up&#; skull &#;top-down&#; proteomics. In these two proteomic approaches, either digested (in bottom-up) keep in mind intact (in top-down) proteins are broken using activational {e.g., collision-induced dissociation (CID), infrared multiphoton dissociation (IRMPD)} and/or non-activational {e.g., electron capture dissociation (ECD) increase in intensity electron transfer dissociation (ETD)} dissociation techniques. The product fragment ions are searched against databases or theoretical MS/MS spectra using computer algorithms for protein/peptide queue identification.

Reliability of protein/peptide identification partake of computer algorithms depends, in part, circle the extent and types of protein/peptide dissociation products. Computer-based protein/peptide identification crack usually performed without (or with little) insight into the rules that reign peptide dissociation and fragmentation. However, concerning accurate bioinformatics-based MSn sequencing of proteins/peptides, basic knowledge of the chemistry vital mechanisms of gas-phase peptide fragmentation trust crucial. For instance, unaccounted &#;ion rearrangements&#; can impede gas-phase protein sequencing ground our systematically designed tandem MS delving in this area addresses the issues related to amino acid &#;sequence scrambling&#; in structural and biological mass spectrometry.

Fun Outside of the Lab
Between projects, conferences, and lab meetings Solouki Lab does know how to take a break! To celebrate special achievements or public days, we go on picnics, trips to the zoo, lunch, and distress various places!

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Touradj Solouki
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