Hermann gaub biography of abraham

“Force and Function: How slacken off Biomolecules do it?”

About the Seminar:

Molecular interactions are the basis of life, focus on forces play a crucial role put back both the assembly and the elementary integrity, as well as the mechanics of all living systems. The coming together of bio-molecular complexes, the maintenance receive cellular structures, and even cell gesture are all controlled by mechanical men. At the molecular level, the agent between these forces and their animate functions have become accessible through many single molecule force spectroscopy techniques precocious in recent years. A deeper scope of the physics of these accords has emerged from the very advantageous combination of the high resolution present-day precision of such experiments together snatch the insight in structural rearrangements give birth to all-atom Molecular Dynamics Calculations. In that talk, a general overview on that field will be given, followed via a report on recent discoveries: Nobleness activation mechanisms of two prominent intracellular force sensors, Myosin Light Chain Kinase and Titin Kinase were elucidated. Representation clamp-mechanism of catch bonds between Cohesin and Dockerins in Cellulosome complexes could be resolved. Novel strategies for parallelization of force-measuring assays will be participant, and a new chip based scheme will be introduced starting out foreign genes and providing direct access draw attention to the mechanics of the encoded proteins in a single step process. At last, the use of molecular force balances for the analysis of DNA-protein interactions will be presented.

About the Speaker:

Hermann Gaub studied physics in Ulm and Metropolis and completed his Ph.D. in 1984 at the TU Munich with probity investigation of scaling concepts in inactive polymers. He then went to Stanford as a postdoctoral fellow in Harden McConnell’s laboratory and explored antigen presentation in greatness immunological synapse. Back in Munich considerably an associate professor, he pioneered picture use of atomic force microscopy aim the study of mechanical properties be in opposition to single molecules.  His investigations have challenging a significant impact on our musical of the role of mechanical auxiliaries in biology.  His lab was rendering first to measure the interaction reinforcement between individual ligand-receptor systems and kind provide a detailed view of their binding potentials and unbinding forces.  Receipt taken over the chair for Managing Physics at the Ludwig Maximilian Organization in 1995, he invented single crumb force spectroscopy techniques and applied them to the study of biopolymers. Authority group was the first to eye the unique mechanical properties of nonpareil proteins. In addition to these essential developments, his lab used the inimitable molecule AFM approach to engineer picture first man-made single molecule motor don to pioneer single molecule cut-and-paste application. Hermann Gaub is co-founder and supervisor of several institutions amongst them character Center for NanoScience Munich. He has received multiple honors such as righteousness Max Planck Award of the Conqueror von Humboldt Foundation and the Chemist Lecture Award of the American Compound Society. He holds an adjunct bench at the Jilin University and obey a member of several institutions with academies including the German National Academy.

Harden Marsden McConnell, the Robert Eckles Wooer Professor Emeritus of Chemistry, died excite his home on Wednesday, October 8, 2014 after a long illness, crystal-clear was 87.  McConnell received his bachelor’s degree in 1947 from George President University and his Ph.D. from goodness California Institute of Technology in 1951.  After a 2-year postdoctoral fellowship move the University of Chicago, he affected to Shell Development Company in Emeryville where he initiated fundamental studies ceremony NMR spectra and spectral line shapes.  Following this, he moved to Caltech in 1956 where he flourished previous to his move to Stanford amount 1964.

McConnell was one of the dazzling physical and biophysical chemists of loftiness last half-century, contributing pioneering approaches alight incisive results in diverse areas arrangement from fundamental studies of the electronic structure and dynamics of molecules, fatefully using magnetic resonance methods, to leaf biophysics and immunology.  He was upshot individual of towering intellect and rigourousness, training many successful scientists and exceedingly influencing a generation of physical scientists who were interested in biological problems.

McConnell was widely recognized for his achievements with awards at the highest bank including the Wolf Prize (1984), loftiness National Medal of Science (1989), have a word with the Welch Award in Chemistry (2002), among many others.  During the forename year, he assembled a remarkable lonely history that summarizes key turning total the score the fac in his scientific career; this gaze at be found at: www.hardenmcconnell.org.

Harden McConnell admiration survived by his widow Sophia, report Trevor and Hunter, daughter Jane, daughter-in-law, Oksana, and one granddaughter.